The KK-Periome database for transcripts of periodontal ligament development

Masahiro Saito, Eisaku Nishida, Takashi Sasaki, Toshiyuki Yoneda, Nobuyoshi Shimizu

研究成果: Article査読

11 被引用数 (Scopus)

抄録

The periodontal ligament (PDL) is a strong connective tissue that surrounds the tooth root, absorbs occlusal forces, and functions as a sense organ. PDL originated from dental follicle (DF), which possessed mesenchymal progenitors in the developing tooth germ. However, as specific marker genes for PDL and DF are currently unavailable, the molecular mechanisms of PDL development are yet to be clarified. To facilitate the identification of such genes, we have previously established a transcriptome database of the human PDL (the KK-Periome database) and screened for specific genes expressed during PDL development. Initial screening of the database revealed two marker genes for distinguishing DF and PDL. The KK-Periome database thus appears to offer a useful resource for investigating genes involved in PDL development.

本文言語English
ページ(範囲)495-502
ページ数8
ジャーナルJournal of Experimental Zoology Part B: Molecular and Developmental Evolution
312
5
DOI
出版ステータスPublished - 2009 7
外部発表はい

ASJC Scopus subject areas

  • 生態、進化、行動および分類学
  • 分子医療
  • 動物科学および動物学
  • 遺伝学
  • 発生生物学

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