The gut–brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation

Nathalie Weltens, Julie Iven, Lukas Van Oudenhove, Michiko Kano

研究成果: Review article査読

13 被引用数 (Scopus)

抄録

Over the past few years, scientific interest in the gut–brain axis (i.e., the bidirectional communication system between the gastrointestinal tract and the brain) has exploded, mostly due to the identification of the gut microbiota as a novel key player in this communication. However, important progress has also been made in other aspects of gut–brain axis research, which has been relatively underemphasized in the review literature. Therefore, in this review, we provide a comprehensive, although not exhaustive, overview of recent research on the functional neuroanatomy of the gut– brain axis and its relevance toward the multidisciplinary field of health neuroscience, excluding studies on the role of the gut microbiota. More specifically, we first focus on irritable bowel syndrome, after which we outline recent findings on the role of the gut–brain axis in appetite and feeding regulation, primarily focusing on the impact of subliminal nutrient-related gut–brain signals. We conclude by providing future perspectives to facilitate translation of the findings from gut–brain axis neuroscientific research to clinical applications in these domains.

本文言語English
ページ(範囲)129-150
ページ数22
ジャーナルAnnals of the New York Academy of Sciences
1428
1
DOI
出版ステータスPublished - 2018 9 1

ASJC Scopus subject areas

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学

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