The GTPase-deficient Rab27A(Q78L) mutant inhibits melanosome transport in melanocytes through Trapping of Rab27A effector protein Slac2-a/Melanophilin in their cytosol: Development of a novel melanosome-targeting tag

Morié Ishida, Saki P. Arai, Norihiko Ohbayashi, Mitsunori Fukuda

    研究成果: Article査読

    9 被引用数 (Scopus)

    抄録

    Background: A GTPase-deficient Rab27A(Q78L) mutation caused perinuclear melanosome aggregation by an unknown mechanism. Results: Forcible targeting of Rab27A(Q78L) to melanosomes by a novel melanosome-targeting tag restored peripheral melanosome distribution in Rab27A-deficient cells. Conclusion: The GTPase activity of Rab27A is required for its melanosome localization, not for melanosome transport. Significance: These findings provide new insights into the mechanism underlying the spatiotemporal regulation of Rab27A activity.

    本文言語English
    ページ(範囲)11059-11067
    ページ数9
    ジャーナルJournal of Biological Chemistry
    289
    16
    DOI
    出版ステータスPublished - 2014 4 18

    ASJC Scopus subject areas

    • 生化学
    • 分子生物学
    • 細胞生物学

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