The glucagon provocative test for the diagnosis and treatment of zollinger-ellison syndrome

Chikashi Shibata, Yuji Funayama, Kouhei Fukushima, Tatsuya Ueno, Atsushi Kohyama, Kennichi Satoh, Tooru Shimosegawa, Tetsuya Yamagiwa, Iwao Sasaki

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Objective Our aim was to determine whether the glucagon provocative test could be used in place of secretin test in patients with gastrinoma. Methods Three patients with gastrinoma underwent the following examinations: (1) preoperative intravenous glucagon test to enable a definitive diagnosis, (2) intra-arterial glucagon injection test to localize the tumor, and (3) intraoperative and postoperative intravenous glucagon test to confirm the completeness of the resection. Results Serum gastrin levels increased in response to intravenous glucagon in all three patients preoperatively. Computed tomography scans revealed a tumor in the lesser omentum, pancreatic head, and the pancreatic uncinate in cases 1, 2, and 3, respectively. Intra-arterial glucagon test revealed that the feeding artery for the tumor was the left gastric artery in case 1 and the superior mesenteric artery in case 3. Resection of the remnant stomach with tumor, pancreaticoduodenectomy with portal vein resection, and enucleation of the tumor were performed in cases 1, 2, and 3, respectively. Serum gastrin levels did not increase in response to intravenous glucagon intraoperatively and postoperatively in cases 1 and 3. Although intravenous glucagon caused a slight increase in serum gastrin in case 2, no recurrent tumors were evident. Conclusion These results indicate that the glucagon provocative test is a suitable alternative to testing with secre tin, which is not commercially available in Japan.

本文言語English
ページ(範囲)344-349
ページ数6
ジャーナルJournal of Gastrointestinal Surgery
12
2
DOI
出版ステータスPublished - 2008

ASJC Scopus subject areas

  • 外科
  • 消化器病学

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