TY - JOUR
T1 - The gene responsible for LEC hepatitis, located on rat chromosome 16, is the homolog to the human wilson disease gene
AU - Sasaki, Nobuya
AU - Hayashizaki, Yoshihide
AU - Muramatsu, Masami
AU - Matsuda, Yoichi
AU - Ando, Yobsuke
AU - Kuramoto, Takashi
AU - Serikawa, Tadao
AU - Azuma, Takachika
AU - Naito, Akihiro
AU - Agui, Takashi
AU - Yamashita, Tadashi
AU - Miyoshi, Ichiro
AU - Takeichi, Noritoshi
AU - Kasai, Noriyuki
PY - 1994/7/15
Y1 - 1994/7/15
N2 - We identified the rat homolog to the human Wilson disease (WD) gene as the gene responsible for hepatitis (hts) in the Long Evans Cinnamon (LEC) rat. A genetic study using fifty-three backcross progenies showed that the rat WD gene detected by Southern blotting using the human WD gene as a probe was tightly linked to the hts phenotype of the LEC rat with no recombination. LEC is a transcriptionally deficient mutant because no transcript of the rat WD gene could be found in the LEC rat by Northern blotting. This rat WD gene was mapped to 16q12.23-12.3 by fluorescence in situ hybridization and mouse × rat somatic cell hybrid analysis.
AB - We identified the rat homolog to the human Wilson disease (WD) gene as the gene responsible for hepatitis (hts) in the Long Evans Cinnamon (LEC) rat. A genetic study using fifty-three backcross progenies showed that the rat WD gene detected by Southern blotting using the human WD gene as a probe was tightly linked to the hts phenotype of the LEC rat with no recombination. LEC is a transcriptionally deficient mutant because no transcript of the rat WD gene could be found in the LEC rat by Northern blotting. This rat WD gene was mapped to 16q12.23-12.3 by fluorescence in situ hybridization and mouse × rat somatic cell hybrid analysis.
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U2 - 10.1006/bbrc.1994.1958
DO - 10.1006/bbrc.1994.1958
M3 - Article
C2 - 8037756
AN - SCOPUS:0027989674
VL - 202
SP - 512
EP - 518
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -