The gene responsible for LEC hepatitis, located on rat chromosome 16, is the homolog to the human wilson disease gene

Nobuya Sasaki, Yoshihide Hayashizaki, Masami Muramatsu, Yoichi Matsuda, Yobsuke Ando, Takashi Kuramoto, Tadao Serikawa, Takachika Azuma, Akihiro Naito, Takashi Agui, Tadashi Yamashita, Ichiro Miyoshi, Noritoshi Takeichi, Noriyuki Kasai

研究成果: Article査読

57 被引用数 (Scopus)

抄録

We identified the rat homolog to the human Wilson disease (WD) gene as the gene responsible for hepatitis (hts) in the Long Evans Cinnamon (LEC) rat. A genetic study using fifty-three backcross progenies showed that the rat WD gene detected by Southern blotting using the human WD gene as a probe was tightly linked to the hts phenotype of the LEC rat with no recombination. LEC is a transcriptionally deficient mutant because no transcript of the rat WD gene could be found in the LEC rat by Northern blotting. This rat WD gene was mapped to 16q12.23-12.3 by fluorescence in situ hybridization and mouse × rat somatic cell hybrid analysis.

本文言語English
ページ(範囲)512-518
ページ数7
ジャーナルBiochemical and biophysical research communications
202
1
DOI
出版ステータスPublished - 1994 7月 15
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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