The gene for component-II of botulinum C2 toxin

Koichi Kimura, Toru Kubota, Iwao Ohishi, Emiko Isogai, Hiroshi Isogai, Nobuhiro Fujii

研究成果: Article査読

31 被引用数 (Scopus)

抄録

The gene encoding component-II of the Clostridium botulinum C2 toxin was cloned from the chromosomal DNA of C. botulinum type C strain (C)-203U28, and the nucleotide sequence was determined. The gene (bc2h) encodes a protein with 721 amino acid residues and is located at 247 bp downstream of the gene for component-I. The N-terminal 16 amino acids were identical to those obtained by analysis of the purified component-II toxin. The ORF for bc2h had only 39% homology at the amino acid level with the C. perfringens iota-lb protein and an ATP/GTP binding site which is present in the iota-lb protein is missing from the protein encoded by bc2h. Both genes had a homologous region that predicts a transmembrane segment.

本文言語English
ページ(範囲)27-34
ページ数8
ジャーナルVeterinary Microbiology
62
1
DOI
出版ステータスPublished - 1998 4 30

ASJC Scopus subject areas

  • 微生物学
  • 獣医学(全般)

フィンガープリント

「The gene for component-II of botulinum C2 toxin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル