The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice

A. Kobayashi, D. S. Donaldson, C. Erridge, T. Kanaya, I. R. Williams, H. Ohno, A. Mahajan, N. A. Mabbott

研究成果: Article査読

56 被引用数 (Scopus)

抄録

The transcytosis of antigens across the follicle-associated epithelium (FAE) of Peyer's patches by microfold cells (M cells) is important for the induction of efficient immune responses to mucosal antigens. The mucosal immune response is compromised by ageing, but effects on M cells were unknown. We show that M-cell density in the FAE of aged mice was dramatically reduced. As a consequence, aged Peyer's patches were significantly deficient in their ability to transcytose particulate lumenal antigen across the FAE. Ageing specifically impaired the expression of Spi-B and the downstream functional maturation of M cells. Ageing also dramatically impaired C-C motif chemokine ligand 20 expression by the FAE. As a consequence, fewer B cells were attracted towards the FAE, potentially reducing their ability to promote M-cell maturation. Our study demonstrates that ageing dramatically impedes the functional maturation of M cells, revealing an important ageing-related defect in the mucosal immune system's ability to sample lumenal antigens.

本文言語English
ページ(範囲)1027-1037
ページ数11
ジャーナルMucosal Immunology
6
5
DOI
出版ステータスPublished - 2013 9月
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

フィンガープリント

「The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル