The Function and Prognostic Significance of Cripto-1 in Colorectal Cancer

Jun Sato, Hideaki Karasawa, Takashi Suzuki, Shun Nakayama, Munetoshi Katagiri, Shimpei Maeda, Shinobu Ohnuma, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was positive in 68 out of 192 cases (35%) by immunohistochemistry. Cripto-1 expression was correlated with worse prognosis and was an independent prognostic factor. Cripto-1-silenced colorectal cancer cell lines had reduced cell proliferation, migration, and activation of Akt and MAPK signaling pathways in vitro, and decreased tumor growth and lymph node metastasis in vivo. Cripto-1 could be a useful prognostic biomarker and therapeutic target in colorectal cancer.

本文言語English
ページ(範囲)214-227
ページ数14
ジャーナルCancer Investigation
38
4
DOI
出版ステータスPublished - 2020 4 20

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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