Continuous ambulatory peritoneal dialysis (CAPD) is now accepted widely as effective dialytic method for chronic renal failure in Japan. The magnesium transfer during CAPD is yet obscure. In this work, we studied the factors affecting transperitoneal magnesium flux in forty seven patients. All patients (forty two men and five women) aged 25-67 years (average 47 years) were treated by CAPD for 0.2-5.4 years (average 2.2 years). They were not medicated vasodilater, steroid hormone or magnesium containing drug. They were medicated calcium carbonate as phosphate binder or calcium supplement and lα-hydroxyvitamin D3(0.25-0.75 μg/day). Their serum level magnesium was 3.21±0.31 mg/dl (mean±SD) and serum albumin level was 3.94±0.44 g/dl (mean±SD). Total magnesium removal was 43.71±4.97 mg/bag (mean±SD) and net magnesium efflux was +5.01±0.72 mg/bag (mean±SD). Transperitoneal magnesium flux was a significant correlation between total drainaged volume (TDV) [Pπ0.01] and serum magnesium concentration level [Pπ0.01]. Effluent magnesium concentration showed no significant correlation to effluent albumin concentration. It was a significant positive correlation to effluent PH [Pπ0.05] and a significant positive correlation to effluent calcium concentrations (total calcium and ionized calcium). However, there was no correlation between total magnesium and total phosphorus concentration in the effluent. Our observations suggest following four points. Firstly, patients treated by CAPD had moderate hypermagnesemia. The transperitoneal magnesium efflux was insufficient. Secondly, factors affecting Mg-mass tranfer were TDV and serum magnesium level. It was suggested that the latter factor was more important than the former. Thirdly, a dialysate containing lower magnesium concentration could be made available to improve hypermagnesemia. Finally, it might be suggested that the diffusable magnesium fraction (ionized and complexed magnesium fraction) was important in regard to transperitoneal magnesium flux.
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