The eyeless homeodomain is dispensable for eye development in Drosophila

C. Punzo, S. Kurata, W. J. Gehring

研究成果: Article査読

53 被引用数 (Scopus)

抄録

Pax-6 genes, known to be essential for eye development, encode an evolutionarily conserved transcription factor with two DNA-binding domains. To corroborate the contribution of each DNA-binding domain to eye formation, we generated truncated forms of the Drosophila Pax-6 gene eyeless and tested their capacity to rescue the ey2 mutant. Surprisingly, EY deleted of the homeodomain rescued the ey2 mutant and triggered ectopic eyes morphogenesis. In contrast, EY lacking the paired domain failed to rescue the ey2 mutant, led to truncation of appendages, and repressed Distal-less when misexpressed. This result suggests distinct functions mediated differentially by the two DNA-binding domains of eyeless.

本文言語English
ページ(範囲)1716-1723
ページ数8
ジャーナルGenes and Development
15
13
DOI
出版ステータスPublished - 2001 7 1
外部発表はい

ASJC Scopus subject areas

  • 遺伝学
  • 発生生物学

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