The eyeless homeodomain is dispensable for eye development in Drosophila

C. Punzo, S. Kurata, W. J. Gehring

研究成果: Article

53 引用 (Scopus)


Pax-6 genes, known to be essential for eye development, encode an evolutionarily conserved transcription factor with two DNA-binding domains. To corroborate the contribution of each DNA-binding domain to eye formation, we generated truncated forms of the Drosophila Pax-6 gene eyeless and tested their capacity to rescue the ey2 mutant. Surprisingly, EY deleted of the homeodomain rescued the ey2 mutant and triggered ectopic eyes morphogenesis. In contrast, EY lacking the paired domain failed to rescue the ey2 mutant, led to truncation of appendages, and repressed Distal-less when misexpressed. This result suggests distinct functions mediated differentially by the two DNA-binding domains of eyeless.

ジャーナルGenes and Development
出版物ステータスPublished - 2001 7 1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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