The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma

Yasuhiro Komuro, Toshiaki Watanabe, Yoshio Hosoi, Yoshihisa Matsumoto, Keiichi Nakagawa, Nelson Tsuno, Shinsuke Kazama, Joji Kitayama, Norio Suzuki, Hirokazu Nagawa

研究成果: Article査読

87 被引用数 (Scopus)

抄録

BACKGROUND. Preoperative radiotherapy reduces the rate of local recurrence and improves the chance of survival in patients with resectable, advanced rectal carcinoma. However, because not all tumors respond similarly to radiation, sorting out suitable patients is required to irradiate tumors rationally. The authors examined the possible role of Ku protein in determining tumor radiosensitivity and disease free survival in patients with rectal carcinoma. METHODS. The authors studied 96 patients with advanced rectal carcinoma. In preradiation biopsy specimens of tumor samples, the number of cells that were stained positive for Ku protein was evaluated by immunohistochemistry. The expression pattern of Ku protein was examined for an association between tumor radiosensitivity (which was determined according to T classification downstaging, complete pathologic response, or Response Evaluation Criteria in Solid Tumors) and disease free survival. RESULTS. There was a high degree of correlation between the percentage of cells that expressed the 70-kDa Ku protein (Ku70) and the 86-kDa Ku protein (Ku86) in the tumor sections (correlation coefficient = 0.85; P < 0.001). The expression pattern of Ku protein was correlated not only with tumor radiosensitivity but also with disease free survival. Pathologic TMN classification, histopathologic grade, and Ku70 expression were significant prognostic variables for disease free survival in a multivariate analysis (P = 0.0031, P = 0.030, and P = 0.023, respectively). CONCLUSIONS. Ku70 and Ku86 raise the predictive possibility of tumor radiosensitivity. Ku may be a useful parameter for selecting patients with rectal carcinoma for preoperative radiotherapy.

本文言語English
ページ(範囲)1199-1205
ページ数7
ジャーナルCancer
95
6
DOI
出版ステータスPublished - 2002 9月 15
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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