The effects of the traditional Chinese medicine, 'Banxia Houpo Tang (Hange-Koboku To)' on the swallowing reflex in Parkinson's disease

K. Iwasaki, Q. Wang, H. Seki, K. Satoh, A. Takeda, H. Arai, H. Sasaki

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Swallowing disorder is common in Parkinson's disease (PD). We studied the swallowing disorder in PD, and tested the efficacy of Banxia Houpo Tang (BHT, a Chinese traditional medicine) in improving the swallowing reflex of PD patients. The Swallowing reflex test is a simple method used to detect swallowing disorders in patients with cerebrovascular disease. Because we observed previously that BHT significantly improved the swallowing reflex in cerebrovascular patients, we studied whether BHT was also effective in improving the swallowing disorder in patients with PD. 23 PD patients (13 males, 10 females, mean age 66.0 ± 9.3, Hoehn and Yahr (H-Y) mean score = 2.8) were evaluated for swallowing reflex and the concentration of substance-P in their saliva before and after 4 weeks of BHT treatment. The swallowing reflex before treatment was significantly delayed, according to the H-Y score (Spearman's p = 0.014, R2 = 0.463). The swallowing reflex before BHT treatment was 3.66 ± 0.98 sec, and after BHT treatment, it improved significantly, to 2.27 ± 0.54 sec (p < 0.0001). Substance-P concentration in PD patients saliva before treatment was significantly lower than in healthy controls (p = 0.007), but showed no significant change after BHT treatment. Our research shows that the swallowing reflex is an effective method to evaluate the swallowing disorder in PD. BHT can significantly improved the swallowing reflex in PD patients, and therefore can be a hopeful candidate for preventing aspiration pneumonia in PD.

本文言語English
ページ(範囲)259-263
ページ数5
ジャーナルPhytomedicine
7
4
DOI
出版ステータスPublished - 2000 7

ASJC Scopus subject areas

  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療

フィンガープリント

「The effects of the traditional Chinese medicine, 'Banxia Houpo Tang (Hange-Koboku To)' on the swallowing reflex in Parkinson's disease」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル