The effect of positive-end-expiratory pressure on stroke volume variation: An experimental study in dogs

Tsuyoshi Nakashima, Yu Kawazoe, Toshie Iseri, Kyohei Miyamoto, Yuka Fujimoto, Seiya Kato

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Stroke volume variation (SVV) may be affected by ventilation settings. However, it is unclear whether positive-end-expiratory pressure (PEEP) affects SVV independently of the effect of driving pressure. We aimed to investigate the effect of driving pressure and PEEP on SVV under various preload conditions using beagle dogs as the animal model. We prepared three preload model, baseline, mild and moderate haemorrhage model. Mild and moderate haemorrhage models were created in nine anaesthetized, mechanically ventilated dogs by sequentially removing 10 mL/kg, and then an additional 10 mL/kg of blood, respectively. We measured cardiac output, stroke volume (SV), SVV, heart rate, central venous pressure, pulmonary capillary wedge pressure and the mean arterial pressure under varying ventilation settings. Peak inspiratory pressure (PIP) was incrementally increased by 4 cmH2O, from 9 cmH2O to 21 cmH2O, under PEEP values of 4, 8, and 12 cmH2O. The driving pressure did not significantly decrease SV under each preload condition and PEEP; however, significantly increased SVV. In contrast, the increased PEEP decreased SV and increased SVV under each preload condition and driving pressure, but these associations were not statistically significant. According to multiple regression analysis, an increase in PEEP and decrease in preload significantly decreased SV (P <.05). In addition, an increase in the driving pressure and decrease in preload significantly increased SVV (P <.05). Driving pressure had more influence than PEEP on SVV.

本文言語English
ページ(範囲)1014-1019
ページ数6
ジャーナルClinical and Experimental Pharmacology and Physiology
47
6
DOI
出版ステータスPublished - 2020 6月 1

ASJC Scopus subject areas

  • 生理学
  • 薬理学
  • 生理学(医学)

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