The effect of liver hydrolysate on chronic ethanol-induced hepatic injury in normal rats

Kotaro Yamada, Kazuma Ueda, Hitoshi Shirakawa, Puspo Edi Giriwono, Satoru Honda, Hidetomo Sakurai, Michio Komai

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The mechanism underlying the improvement in hepatic function by liver hydrolysate (LH) after ethanol-induced hepatic injury is unclear. Therefore, we investigated the effects of LH administration on chronic ethanol-induced hepatic injury in normal rats and the mechanism underlying the improvement of its symptoms by LH. LH attenuated liver damage and reduced oxidative stress after chronic ethanol-induced hepatic injury in normal rats. LH treatment reduced hepatic injury biomarkers of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT). LH treatment also decreased levels of 8-hydroxy-deoxyguanosine (8-OHdG) as oxidative stress marker. LH may prove beneficial to prevent the liver damage of chronic ethanol, at least in part, by alleviating oxidative stress.

本文言語English
ページ(範囲)554-557
ページ数4
ジャーナルBiological and Pharmaceutical Bulletin
43
3
DOI
出版ステータスPublished - 2020 3 1

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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