The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells

Kei Ito, Wakae Awano, Kazumi Suzuki, Yasushi Hiromi, Daisuke Yamamoto

    研究成果: Article査読

    631 被引用数 (Scopus)

    抄録

    The mushroom body (MB) is an important centre for higher order sensory integration and learning in insects. To analyse the development and organisation of the MB neuropile in Drosophila, we performed cell lineage analysis in the adult brain with a new technique that combines the Flippase (flp)/FRT system and the GAL4/UAS system. We showed that the four mushroom body neuroblasts (MBNbs) give birth exclusively to the neurones and glial cells of the MB, and that each of the four MBNb clones contributes to the entire MB structure. The expression patterns of 19 GAL4 enhancer-trap strains that mark various subsets of MB cells revealed overlapping cell types in ail four of the MBNb lineages. Partial ablation of MBNbs using hydroxyurea showed that each of the four neuroblasts autonomously generates the entire repertoire of the known MB substructures.

    本文言語English
    ページ(範囲)761-771
    ページ数11
    ジャーナルDevelopment
    124
    4
    出版ステータスPublished - 1997 2

    ASJC Scopus subject areas

    • 分子生物学
    • 発生生物学

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