The Dmca1D channel mediates Ca2+ inward currents in Drosophila embryonic muscles

Yusuke Hara, Masayuki Koganezawa, Daisuke Yamamoto

    研究成果: Article査読

    5 被引用数 (Scopus)

    抄録

    We studied, in a genetic model organism, Drosophila melanogaster, the channel mechanisms underlying membrane excitation in the embryonic body wall muscle whose biophysical properties have been poorly characterized. The inward current underlying the action potential was solely mediated by a high-threshold class of voltage-gated Ca2+ channels, which exhibited slow inactivation, Ca2+ permeability with saturation at high [Ca2+]OUT, and sensitivity to a Ca2+ channel blocker, Cd2+. The Ca2+ current in the embryonic muscle was completely eliminated in Dmca1D mutants, indicating that the Dmca1D-encoded Ca2+ channel is the major mediator of inward currents in the body wall muscles throughout the embryonic and larval stages.

    本文言語English
    ページ(範囲)117-123
    ページ数7
    ジャーナルJournal of neurogenetics
    29
    2-3
    DOI
    出版ステータスPublished - 2015 7 3

    ASJC Scopus subject areas

    • 遺伝学
    • 細胞および分子神経科学

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