The distribution of [11C]cocaine in normal and cocaine-sensitization mice

Michinao Mizugaki, Takanori Hishinuma, Katsuhiko Kimura, Hitoshi Nakamura, Hisashi Aso, Fumio Ishii, Masazumi Nishikawa, Kunihiko Itoh, Yoshihisa Tomioka, Shunji Ishiwata, Hiroshi Moritani, Taizo Uyama, Tatsuo Ido

研究成果: Article査読

5 被引用数 (Scopus)

抄録

[N-11C-methyl]-cocaine ([11C]cocaine), synthesized by N-methylation of norcocaine with [11C]CH3I, was used to assist in imaging the variety of local distribution by positron emission tomography (PET). The radiochemical yield and the radiochemical purity after purification of [11C]cocaine by high performance liquid chromatography (HPLC) at a sp. act. of 814GBq/mmol were 47-58% and > 99%, respectively. The time required for synthesis including the purification was 25-30 min from the end of [11C]CH3I trapping. The physical distribution of [11C]cocaine in organ was also investigated in mice at various time after i.v. injection. The main accumulation of radioactivity occurred in the lung, kidney and brain within l min after the injection. In the brain, no differences in the organ were observed except the radioactivity level in each section increased for the first 5 min, since then radioactivity decreased dramatically. Furthermore, in the behavioral sensitization model of cocaine, the peak of [11C]cocaine uptake in each brain area was shown to be 5-15 min.

本文言語English
ページ(範囲)793-799
ページ数7
ジャーナルNuclear Medicine and Biology
21
6
DOI
出版ステータスPublished - 1994 8

ASJC Scopus subject areas

  • 分子医療
  • 放射線学、核医学およびイメージング
  • 癌研究

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