Purpose To assess the current status in Japan of the treatment for squamous cell carcinoma of the T4 maxillary sinus (MS-SCC)and its use to plan clinical trials in the future. Patients The data for 128 patients with previously untreated MS-SCC were obtained from 28 institutions from 2006 to 2007. Of the 128 patients, 118 patients with curative intent were included in an analysis of the treatment and its results. Results Of the 118 patients, 73 patients had T4a disease, and 45 with T4b. Thirty-nine patients (33.1%)were treated with total maxillectomy, 25 (21.2%)with partial maxillectomy, 22 patients (18.6%)with RAD-PLAT, 19 patients (16.1%)with IV-CRT, and 13 patients (11.0%)with others. The 5-year overall survival rate and local control rate for 118 patients were 49.8% and 48.9%, respectively. The 5-year overall survival rates for patients with T4aN0M0 and T4bN0M0 were 67.5% and 29.8%, respectively. Conclusion This study was retrospective, but we could understand the tendency of treatment choice and treatment results. It will be useful information to plan clinical trials in the future.
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