The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila

Zahid Sadek Chowdhury, Kosei Sato, Daisuke Yamamoto

    研究成果: Article査読

    10 被引用数 (Scopus)

    抄録

    In fruit flies, the male-specific fruitless (fru) gene product FruBM plays a central role in establishing the neural circuitry for male courtship behavior by orchestrating the transcription of genes required for the male-type specification of individual neurons. We herein identify the core promoter recognition factor gene Trf2 as a dominant modifier of fru actions. Trf2 knockdown in the sexually dimorphic mAL neurons leads to the loss of a male-specific neurite and a reduction in male courtship vigor. TRF2 forms a repressor complex with FruBM, strongly enhancing the repressor activity of FruBM at the promoter region of the robo1 gene, whose function is required for inhibiting the male-specific neurite formation. In females that lack FruBM, TRF2 stimulates robo1 transcription. Our results suggest that TRF2 switches its own role from an activator to a repressor of transcription upon binding to FruBM, thereby enabling the ipsilateral neurite formation only in males.

    本文言語English
    論文番号1480
    ジャーナルNature communications
    8
    1
    DOI
    出版ステータスPublished - 2017 12月 1

    ASJC Scopus subject areas

    • 化学 (全般)
    • 生化学、遺伝学、分子生物学(全般)
    • 物理学および天文学(全般)

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