The complex relationship of gene duplication and essentiality

Takashi Makino, Karsten Hokamp, Aoife McLysaght

研究成果: Short survey

62 引用 (Scopus)

抜粋

In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes.

元の言語English
ページ(範囲)152-155
ページ数4
ジャーナルTrends in Genetics
25
発行部数4
DOI
出版物ステータスPublished - 2009 4 1
外部発表Yes

ASJC Scopus subject areas

  • Genetics

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