The in vitro and in vivo combination effect of antifungal agents was investigated. The combination of amphotericin B (AMPH) plus fluconazole (FLCZ) had a synergistic effect against Candida spp. The combination of flucytosine (5-FC) plus FLCZ had a synergistic effect against Cryptococcus neoformans isolated clinically, and the combination of AMPH plus miconazole (MCZ) was synergistic against Aspergillus fumigatus. Treatment of FLCZ plus 5-FC was shown efficacious in three cases of pulmonary cryptococcosis. Twenty cases of deep-seated mycosis were treated by the combination of MCZ plus 5-FC: seven cases showed improvement, in six cases fungi were eradicated, and side effects occurred in ten cases.
ASJC Scopus subject areas
- Infectious Diseases