The carboxy-terminal region of SMAP2 directs subcellular localization as well as Arf protein specificity

Ikuko Sakakura, Kenji Tanabe, Natsumi Nouki, Mai Suzuki, Masanobu Satake, Toshio Watanabe

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Small G proteins play a central role in the organization of secretory and endocytotic pathways. The recruitment of some effectors, including vesicle coat proteins, is mediated by the ADP-ribosylation factor (Arf) family. Arf proteins have distinct subcellular localizations. ArfGAPs (Arf GTPase-activating proteins) regulate Arf GTPase activity. Thus, each ArfGAP is distinctly localized to allow it to maintain a specific interaction with its target Arf(s). However, the domains that regulate the subcellular localization of ArfGAPs and the way in which these subcellular localizations affect the target specificities of ArfGAPs remain unclear. Recently, we identified two novel ArfGAPs, SMAP1 (Small ArfGAP protein 1) and SMAP2. In the current study, we identified sequences in the carboxy-terminal region of SMAP2 that are critical for its specific subcellular localization and its specificity for Arf proteins.

本文言語English
ページ(範囲)661-666
ページ数6
ジャーナルBiochemical and biophysical research communications
404
2
DOI
出版ステータスPublished - 2011 1 14
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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