The brain-specific actin-related protein ArpNα interacts with the transcriptional co-repressor CtBP

Yukako Oma, Katsuhiko Nishimori, Masahiko Harata

研究成果: Article

16 引用 (Scopus)

抜粋

Actin-related protein (Arp) is found in many chromatin remodeling and histone acetyltransferase complexes. We previously identified ArpNα as an isoform of ArpNβ/BAF53, which is included in mammalian SWI/SNF chromatin remodeling complex, and showed that ArpNα is a potential component of the complex. Although it has a structure highly similar to ArpNβ/BAF53, ArpNα is expressed exclusively in brain and in neural differentiated embryonal carcinoma cells. Since ArpNα possesses a region that shows low similarity to ArpNβ/BAF53, we hypothesized that proteins interacting with this region contribute to the ArpNα-specific function in brain. Here we showed that ArpNα, but not ArpNβ/BAF53, interacts with the transcriptional co-repressor CtBP (C-terminal binding protein). Transactivation by the SWI/SNF complex and glucocorticoid receptor was repressed by the CtBP in the presence of ArpNα. These findings suggest that SWI/SNF complex containing ArpNα might regulate certain genes involved in brain development and/or its function differently from SWI/SNF complex containing ArpNβ/BAF53.

元の言語English
ページ(範囲)521-528
ページ数8
ジャーナルBiochemical and biophysical research communications
301
発行部数2
DOI
出版物ステータスPublished - 2003 2 7

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

フィンガープリント The brain-specific actin-related protein ArpNα interacts with the transcriptional co-repressor CtBP' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用