The area under curve for time-course analysis parameters is associated with abdominal aortic aneurysms and the severity of peripheral artery disease in men

Nao Konno, Taku Harada, Daijirou Akamatsu, Hitoshi Goto, Takashi Miki, Takashi Kamei, Masahiro Kohzuki

研究成果: Article査読

抄録

Background: Abdominal aortic aneurysm (AAA) and peripheral artery disease (PAD) are associated with vascular endothelial dysfunction. To date, flow-mediated vasodilatation (FMD) and nitroglycerin-mediated vasodilatation (NMD) have been used to evaluate vascular function. Recently, parameters of time-course analysis have been proposed as useful evaluations for arteriosclerotic diseases. In this study, the correlation between the parameters of time-course analysis, to the degree of vascular endothelial damage in AAA and PAD, together with their applicability as a vascular function test, was investigated. Methods: Brachial artery vasoreactivity was assessed in male patients with AAA (n = 150) and PAD (n = 50). The percentage change in peak diameters (ΔFMD and ΔNMD), the time to diameter change, the time to peak diameter from the diameter change, the blood flow decay time constant, the area under the curve (AUC), the maximum dilation rate and the extended time constant were measured. Results: Among the groups of aneurysm diameter in AAA, the FMD-AUC was highly different (p =.01), while the ΔFMD was not significantly different (p =.36). Among the Fontaine stages in PAD, the FMD-AUC was inversely associated with severity (p =.01) although the ΔFMD was not significantly different (p =.71). Among the Fontaine stages, the NMD-AUC was also inversely associated with severity (p =.03) although the ΔNMD was not significantly different (p =.11). Conclusion: This study suggests that FMD-AUC and NMD-AUC are useful for estimating vascular endothelial and vascular smooth muscle dysfunction, serving as supplementary markers for the diagnosis and evaluation of PAD and AAA.

本文言語English
論文番号100080
ジャーナルInternational Journal of Cardiology: Hypertension
8
DOI
出版ステータスPublished - 2021 3

ASJC Scopus subject areas

  • 内科学
  • 循環器および心血管医学

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