The apolipoprotein E gene in Binswanger's disease and vascular dementia

Susumu Higuchi, Hiroyuki Arai, Takuma Nakagawa, Taro Muramatsu, Hidetada Sasaki, John Q. Trojanowski

研究成果: Article査読

24 被引用数 (Scopus)

抄録

We investigated the polymorphism of the apolipoprotein E (ApoE) gene using a PCR-RFLP method in patients with Binswanger's disease (BD), non-BD vascular dementia, or Alzheimer's disease (AD). The frequency of the ε4 allele of the ApoE (ApoE4) in BD patients and non-BD vascular dementia patients did not differ from that observed in the non-demented elderly controls, but it was significantly lower than the frequency in AD patients. These results and other recent observations suggest that one or more factors other than the ApoE gene contribute to the pathogenesis of dementia in BD and non-BD vascular dementia.

本文言語English
ページ(範囲)459-461
ページ数3
ジャーナルClinical Genetics
50
6
DOI
出版ステータスPublished - 1996 12
外部発表はい

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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