The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival

Yoshifumi Takahashi, Yasushi Saga, Takahiro Koyanagi, Yuji Takei, Sizuo Machida, Akiyo Taneichi, Hiroaki Mizukami, Yasufumi Sato, Shigeki Matsubara, Hiroyuki Fujiwara

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Vasohibin-1 (VASH1) is expressed in vascular endothelial cells stimulated by several angiogenic growth factors and displays autocrine activity to regulate angiogenesis via a negative feedback mechanism. In this study, we investigated the effect of VASH1 on ovarian cancer progression using VASH1-expressing ovarian cancer cells in vitro and in vivo. The growth ability of ovarian cancer cells engineered to express the VASH1 gene remained unchanged in vitro. However, we showed that VASH1 secretion by tumor cells inhibited the growth of human umbilical vein endothelial cells. Further, animal experiments showed that VASH1 expression inhibited tumor angiogenesis and growth. In a murine model of peritoneal dissemination of ovarian cancer cells, VASH1 inhibited peritoneal dissemination and ascites, resulting in significantly prolonged survival in mice. This indicates that VASH1 exerts an antitumor effect on ovarian cancer by inhibiting angiogenesis in the tumor environment. These findings suggest that a novel therapy based on VASH1 could be a useful therapeutic strategy for ovarian cancer.

本文言語English
ページ(範囲)2057-2063
ページ数7
ジャーナルInternational journal of oncology
47
6
DOI
出版ステータスPublished - 2015 12

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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