抄録
TDP-43 and FUS are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), and loss of function of either protein contributes to these neurodegenerative conditions. To elucidate the TDP-43- and FUS-regulated pathophysiological RNA metabolism cascades, we assessed the differential gene expression and alternative splicing profiles related to regulation by either TDP-43 or FUS in primary cortical neurons. These profiles overlapped by >25% with respect to gene expression and >9% with respect to alternative splicing. The shared downstream RNA targets of TDP-43 and FUS may form a common pathway in the neurodegenerative processes of ALS/FTLD.
本文言語 | English |
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ページ(範囲) | 1-10 |
ページ数 | 10 |
ジャーナル | FEBS Open Bio |
巻 | 4 |
DOI | |
出版ステータス | Published - 2014 |
外部発表 | はい |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)