The airway antigen sampling system: Respiratory M cells as an alternative gateway for inhaled antigens

Dong Young Kim, Ayuko Sato, Satoshi Fukuyama, Hiroshi Sagara, Takahiro Nagatake, Il Gyu Kong, Kaoru Goda, Tomonori Nochi, Jun Kunisawa, Shintaro Sato, Yoshifumi Yokota, Chul Hee Lee, Hiroshi Kiyono

研究成果: Article査読

62 被引用数 (Scopus)

抄録

In this study, we demonstrated a new airway Ag sampling site by analyzing tissue sections of the murine nasal passages.We revealed the presence of respiratoryMcells, which had the ability to take up OVA and recombinant Salmonella typhimurium expressing GFP, in the turbinates covered with single-layer epithelium. These M cells were also capable of taking up respiratory pathogen group A Streptococcus after nasal challenge. Inhibitor of DNA binding/differentiation 2 (Id2)-deficient mice, which are deficient in lymphoid tissues, including nasopharynx-associated lymphoid tissue, had a similar frequency of M cell clusters in their nasal epithelia to that of their littermates, Id2+ mice. The titers of Ag-specific Abs were as high in Id2-/- mice as in Id2+/- mice after nasal immunization with recombinant Salmonella-ToxC or group A Streptococcus, indicating that respiratory M cells were capable of sampling inhaled bacterial Ag to initiate an Ag-specific immune response. Taken together, these findings suggest that respiratory M cells act as a nasopharynx-associated lymphoid tissue-independent alternative gateway for Ag sampling and subsequent induction of Ag-specific immune responses in the upper respiratory tract.

本文言語English
ページ(範囲)4253-4262
ページ数10
ジャーナルJournal of Immunology
186
7
DOI
出版ステータスPublished - 2011 4 1
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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