The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factor

Yukikazu Numata, Tadashi Terui, Ryuhei Okuyama, Noriyasu Hirasawa, Yoshie Sugiura, Ichiro Miyoshi, Takehiko Watanabe, Atsuo Kuramasu, Hachiro Tagami, Hiroshi Otsu

研究成果: Article査読

55 被引用数 (Scopus)

抄録

This study revealed that the absence of histamine in histidine decarboxylase gene-knockout (HDC-/-) mice resulted in delayed cutaneous wound healing and that exogenously administered histamine compensated this process. With the overproduction of histamine in HDC gene-transgenic mice, the healing was accelerated compared to the HDC+/+ mice. These results indicate that histamine positively accelerated the cutaneous wound healing. Macrophage recruitment and angiogenesis at the wound edge were specifically impaired in HDC-/- mice, and histamine-treated wounds in HDC-/- mice demonstrated increased macrophage recruitment and angiogenesis. The amount of basic fibroblast growth factor (bFGF) in protein level at the wound edge was higher in HDC+/+ mice, especially on the 3rd and 5th day of wound healing compared to those in HDC-/- mice. Topically administered SU5402, a specific antagonist to fibroblast growth factor receptor-1 tyrosine kinase, to the wound surface suppressed the wound healing in HDC+/+ mice but not in HDC-/- mice. Moreover, SU5402 reduced macrophage recruitment and angiogenesis in HDC+/+ mice. From these observations, it was concluded that the accelerated wound-healing activity of histamine was mediated by the activity of bFGF, which leads to angiogenesis, and macrophage recruitment in the wound-healing process.

本文言語English
ページ(範囲)1403-1409
ページ数7
ジャーナルJournal of Investigative Dermatology
126
6
DOI
出版ステータスPublished - 2006 6

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 皮膚病学
  • 細胞生物学

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