The 1975 Japanese diet has a stress reduction effect in mice: Search for physiological effects using metabolome analysis

Yui Iwagaki, Saeko Sugawara, Yasuhisa Huruya, Miki Sato, Qiming Wu, E. Shuang, Kazushi Yamamoto, Tsuyoshi Tsuduki

研究成果: Article査読

13 被引用数 (Scopus)

抄録

We aimed to find new physiological effects of the Japanese diet. First, to determine the key components in serum from mice fed the 1975 diet, serum from mice fed the 1960, 1975, 1990 or 2005 Japanese diet was analyzed using CE-TOFMS and LC-TOFMS. Based on these results, the key components were determined by principal component analysis. Among the identified compounds, GABA was included. Therefore, a stress reduction effect was inferred as a novel physiological effect of this diet. Next, we tested whether the 1975 diet had an actual stress reduction effect in mice. Mice were given the 1975 diet or a control diet for 4 weeks, after which they were divided into restraint stress and non-stress groups. Mice fed the 1975 diet had significantly decreased stress parameters compared with those fed the control diet. These results provide the first evidence that the 1975 Japanese diet has a stress reduction effect.

本文言語English
ページ(範囲)709-715
ページ数7
ジャーナルBioscience, Biotechnology and Biochemistry
82
4
DOI
出版ステータスPublished - 2018

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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