Terahertz irradiation effects on the morphology and dynamics of actin biopolymer

Hiromichi Hoshina, Shota Yamazaki, Masaaki Tsubouchi, Masahiko Harata

研究成果: Article査読

抄録

Our recent experimental research on terahertz (THz) irradiation of actin filaments, which serve as representative biopolymer materials, is summarized in this review. We found that pulsed THz waves with energy density of ∼104 J cm2 (∼108 W cm2 at the peak) generate acoustic waves efficiently in the aqueous media. These acoustic waves propagated deeply into the water and demolished the actin filaments in living HeLa cells that were submerged into the cell culture medium. The results implied that THz pulsed irradiation affects the biomolecules in the tissues, even if these molecules are located a few millimeters away from the body surface. In contrast, irradiation using THz waves with lower peak power of the order of ∼W cm2 induces the elongation of the actin biopolymer without thermal or acoustic effects. The polymerization of actin molecules plays essential roles in cell motility, growth, differentiation and gene expression. Therefore, our results indicate that THz waves could be applicable to artificial manipulation of cellular functions.

本文言語English
論文番号034015
ジャーナルJPhys Photonics
3
3
DOI
出版ステータスPublished - 2021 7

ASJC Scopus subject areas

  • 原子分子物理学および光学
  • 電子材料、光学材料、および磁性材料
  • 電子工学および電気工学

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