TY - JOUR
T1 - Temporo-parietal theta activity correlates with misery perfusion in arterial occlusive disease
AU - Ohtomo, Satoru
AU - Nakasato, Nobukazu
AU - Shimizu, Hiroaki
AU - Seki, Shintarou
AU - Kanno, Akitake
AU - Kumabe, Toshihiro
AU - Tominaga, Teiji
N1 - Funding Information:
This work was supported by the Open Competition for the Development of Innovative Technology (No. 12208) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. We thank Drs. Masayuki Ezura, Satoru Fujiwara, and Norio Taira, and the staff of Kohnan Hospital Ryogo Center for their continuous support of this work.
PY - 2009/7
Y1 - 2009/7
N2 - Objective: Temporo-parietal theta activity (TPTA), often detected in hemispheres with internal carotid (ICA) or middle cerebral artery (MCA) occlusive lesions, is more clearly separated from occipital alpha activity by magnetoencephalography (MEG) than electroencephalography. The present study investigated whether TPTA is correlated with misery perfusion, a surgically correctable type of hemodynamic impairment. Methods: Awake MEG was measured in 56 patients with ICA or MCA occlusive lesions. Regional cerebral blood flow (rCBF) and regional cerebrovascular reactivity (rCVR) to acetazolamide were measured in the MCA territory by xenon-133 single-photon emission computed tomography. MEG was repeated in 10 patients after vascular reconstruction surgery. Results: Fourteen patients showed TPTA in the lesion hemisphere (n = 13) or bilaterally (n = 1). The presence of TPTA was significantly correlated with both reduced rCBF and reduced rCVR (P = 0.0009). After surgery, TPTA disappeared in 7 of the 10 studied patients. Conclusions: The presence of TPTA suggests misery perfusion, which is characterized by reduced rCBF and reduced rCVR. Significance: MEG can detect the presence of reversible and surgically remediable cerebral ischemia before the development of complete infarction.
AB - Objective: Temporo-parietal theta activity (TPTA), often detected in hemispheres with internal carotid (ICA) or middle cerebral artery (MCA) occlusive lesions, is more clearly separated from occipital alpha activity by magnetoencephalography (MEG) than electroencephalography. The present study investigated whether TPTA is correlated with misery perfusion, a surgically correctable type of hemodynamic impairment. Methods: Awake MEG was measured in 56 patients with ICA or MCA occlusive lesions. Regional cerebral blood flow (rCBF) and regional cerebrovascular reactivity (rCVR) to acetazolamide were measured in the MCA territory by xenon-133 single-photon emission computed tomography. MEG was repeated in 10 patients after vascular reconstruction surgery. Results: Fourteen patients showed TPTA in the lesion hemisphere (n = 13) or bilaterally (n = 1). The presence of TPTA was significantly correlated with both reduced rCBF and reduced rCVR (P = 0.0009). After surgery, TPTA disappeared in 7 of the 10 studied patients. Conclusions: The presence of TPTA suggests misery perfusion, which is characterized by reduced rCBF and reduced rCVR. Significance: MEG can detect the presence of reversible and surgically remediable cerebral ischemia before the development of complete infarction.
KW - Brain infarction
KW - Carotid stenosis
KW - Cerebrovascular circulation
KW - Magnetoencephalography
KW - Theta activity
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U2 - 10.1016/j.clinph.2009.05.015
DO - 10.1016/j.clinph.2009.05.015
M3 - Article
C2 - 19539523
AN - SCOPUS:67649859275
SN - 1388-2457
VL - 120
SP - 1227
EP - 1234
JO - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
JF - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
IS - 7
ER -