Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 Domain

Katsunori Tanaka, Sanae Shirotsuki, Takayuki Iwata, Chika Kageyama, Tsuyoshi Tahara, Satoshi Nozaki, Eric R.O. Siwu, Satoru Tamura, Shunsuke Douke, Nobutoshi Murakami, Hirotaka Onoe, Yasuyoshi Watanabe, Koichi Fukase

研究成果: Review article査読

6 被引用数 (Scopus)

抄録

A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.

本文言語English
ページ(範囲)637-645
ページ数9
ジャーナルACS Chemical Biology
7
4
DOI
出版ステータスPublished - 2012 4 20

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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