Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos

Satoru Tamura, Gang Ming Yang, Natsuko Yasueda, Yoshiharu Matsuura, Yasumasa Komoda, Nobutoshi Murakami

研究成果: Article

11 引用 (Scopus)

抜粋

By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.

元の言語English
ページ(範囲)1598-1600
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
20
発行部数5
DOI
出版物ステータスPublished - 2010 3 1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • これを引用

    Tamura, S., Yang, G. M., Yasueda, N., Matsuura, Y., Komoda, Y., & Murakami, N. (2010). Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos. Bioorganic and Medicinal Chemistry Letters, 20(5), 1598-1600. https://doi.org/10.1016/j.bmcl.2010.01.084