Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase

Masaki Saito, Ayano Chiba, Takeya Sato, Takahiro Moriya, Jun Sukegawa, Norimichi Nakahata

研究成果: Article査読

抄録

Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown. We have previously shown that Tctex-1 (or DYNLT1) can interact with the parathyroid hormone receptor (PTHR). In the present study, we investigated the role of Tctex-1 in the PTHR signaling and found that Tctex-1 augmented the PTHR-mediated Gs/adenylyl cyclase (AC) pathway by activating AC regardless of the binding to PTHR. Furthermore, Tctex-1 directly bound to AC type 6. These data demonstrate a novel mechanism underlying GPCR/Gs signaling regulated by Tctex-1.

本文言語English
ページ(範囲)150-154
ページ数5
ジャーナルJournal of Pharmacological Sciences
145
1
DOI
出版ステータスPublished - 2021 1

ASJC Scopus subject areas

  • 分子医療
  • 薬理学

フィンガープリント

「Tctex-1 augments G protein-coupled receptor-mediated G<sub>s</sub> signaling by activating adenylyl cyclase」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル