Taurocholate-induced gastric damage in rats with obstructive jaundice

T. Matsuo, I. Sasaki, Y. Kamiyama, H. Naitoh, Y. Funayama, M. Takahashi, K. Fukushima, S. Matsuno

研究成果: Article査読

10 被引用数 (Scopus)

抄録

We examined the severity of taurocholate-induced gastric mucosal damage in rats with obstructive jaundice. Oral administration of 100 mM taurocholate induced severer gastric mucosal damage in rats with jaundice than in intact rats. Pretreatment with 5 mM taurocholate significantly protected the gastric mucosa against 100 mM taurocholate-induced damage, suggesting adaptive cytoprotection in rats with jaundice. The reductions in the gastric mucosal potential difference and hexosamine contents in the gastric mucosa in response to 100 mM taurocholate were significantly attenuated by prior administration of 5 mM taurocholate in both intact rats and rats with jaundice.

本文言語English
ページ(範囲)83-86
ページ数4
ジャーナルScandinavian journal of gastroenterology
24
S162
DOI
出版ステータスPublished - 1989

ASJC Scopus subject areas

  • 消化器病学

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