Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain

Rie Kusano, Kousuke Fujita, Yasuharu Shinoda, Yuko Nagaura, Hiroshi Kiyonari, Takaya Abe, Toshio Watanabe, Yasuhisa Matsui, Masahiro Fukaya, Hiroyuki Sakagami, Tatsuya Sato, Jun Ichi Funahashi, Motoko Ohnishi, Shinri Tamura, Takayasu Kobayashi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

PPM1L, a member of the metal-dependent protein phosphatase (PPM) family, is involved in regulating the stress-activated protein kinase pathway and ceramide trafficking. However, the physiological function of PPM1L in the brain is unclear. In this study, we generated and analyzed ppm1l-deficient mice in order to investigate PPM1L functions in the brain. Our results indicate that ppm1l is highly expressed in the central nervous system during mouse development and that ppm1lΔ/Δ mice display impaired motor performance and morphological abnormalities in the forebrain. Electron microscopic and immunohistochemical analyses suggest that these abnormalities are due to impaired axonal tract formation. Our novel findings suggest an important role for PPM1L in brain development.

本文言語English
ページ(範囲)3606-3615
ページ数10
ジャーナルFEBS Letters
590
20
DOI
出版ステータスPublished - 2016 10月 1

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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