TY - JOUR
T1 - Tag-reporter and resin capture - Release strategy in oligosaccharide synthesis
AU - Ito, Yukishige
AU - Manabe, Shino
PY - 2002/7/15
Y1 - 2002/7/15
N2 - Low molecular weight poly(ethylene glycol) (LWPEG) has been found to be useful as a "tag" in oligosaccharide synthesis due to its high polarity. Realtime reaction monitoring was achieved by use of MALDI-TOF MS in the glycosylation reactions and color tests in the deprotection of the chloroacetyl group. Further, a cysteine-supported insoluble resin enables the purification of the chloroacetyl-bound compounds on soluble PEG.
AB - Low molecular weight poly(ethylene glycol) (LWPEG) has been found to be useful as a "tag" in oligosaccharide synthesis due to its high polarity. Realtime reaction monitoring was achieved by use of MALDI-TOF MS in the glycosylation reactions and color tests in the deprotection of the chloroacetyl group. Further, a cysteine-supported insoluble resin enables the purification of the chloroacetyl-bound compounds on soluble PEG.
KW - Capture-release purification
KW - Oligosaccharides
KW - Polymer-supported synthesis
KW - Real-time monitoring
KW - Synthesis design
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U2 - 10.1002/1521-3765(20020715)8:14<3076::AID-CHEM3076>3.0.CO;2-N
DO - 10.1002/1521-3765(20020715)8:14<3076::AID-CHEM3076>3.0.CO;2-N
M3 - Article
C2 - 12203337
AN - SCOPUS:0037101669
VL - 8
SP - 3076
EP - 3084
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
SN - 0947-6539
IS - 14
ER -