We report two patients with non-Hodgkin's lymphoma whose neoplastic cells had rearranged T cell γ chain (Tγ) genes, and had the germ line DNA to T cell receptor β chain (Tβ) and immunoglobulin genes. Surface marker analysis of the neoplastic cells revealed that leukemic cells from one patient were derived from common thymocytes, while in the other patient the clonality and cell linage could not be identified, probably due to the low percentage of neoplastic cells in the specimen. No phenotypic changes were observed after cultivation with phorbol myristate acetate, except for induction of Tac antigens on cells of one patient. Leukemic cells with only the Tγ gene rearrangement are thought to be precursor T cells that differentiate into mature T cells following Tβ gene rearrangement. This suggests that such T cells with only the Tγ gene rearrangement exist among common thymocytes.
|出版ステータス||Published - 1987|
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