TY - CHAP
T1 - Systems biology approaches in breast cancer studies
AU - Wang, Zhiwei
AU - Shaik, Shavali
AU - Inuzuka, Hiroyuki
AU - Wei, Wenyi
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Breast cancer is the second most common malignancy for women. Currently, only several prognostic and predictive factors are used clinically for managing breast cancer patients. Recently, systems biology approaches based on high-throughput technologies such as DNA microarrays, mass spectrometry-based proteomics and metabolomics have began to be used to investigate the expression of a wide range of genes and proteins in the dissected breast tumors. Moreover, these expression signatures have been found to provide potential and independent prognostic information in patients diagnosed with breast cancer. Furthermore, these molecular signatures could not only help to identify new therapeutic targets, but also allow physicians to design more effective and targeted therapeutic strategies for achieving better treatment outcomes of breast cancer patients.
AB - Breast cancer is the second most common malignancy for women. Currently, only several prognostic and predictive factors are used clinically for managing breast cancer patients. Recently, systems biology approaches based on high-throughput technologies such as DNA microarrays, mass spectrometry-based proteomics and metabolomics have began to be used to investigate the expression of a wide range of genes and proteins in the dissected breast tumors. Moreover, these expression signatures have been found to provide potential and independent prognostic information in patients diagnosed with breast cancer. Furthermore, these molecular signatures could not only help to identify new therapeutic targets, but also allow physicians to design more effective and targeted therapeutic strategies for achieving better treatment outcomes of breast cancer patients.
KW - DNA microarray
KW - Dissociable antibody microarray (DAMA)
KW - Estrogen receptor (ER)
KW - Factors for increased breast cancer incidence
KW - Gene annotation tool to help explain relationships (GATHER)
KW - Human epidermal growth factor receptor 2 (Her2)
KW - Mass spectrometry-based proteomics
KW - Metabolomics
KW - MicroRNA microarray
KW - Progesterone receptor (PR)
KW - Systems biology
KW - Systems biology approaches
KW - Tissue microarray
KW - Triple-negative breast cancers (TNBC)
KW - cDNA-mediated annealing selection extension and ligation (DASL)
UR - http://www.scopus.com/inward/record.url?scp=84949179950&partnerID=8YFLogxK
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U2 - 10.1007/978-1-4614-5647-6_18
DO - 10.1007/978-1-4614-5647-6_18
M3 - Chapter
AN - SCOPUS:84949179950
SN - 1461456460
SN - 9781461456469
VL - 9781461456476
SP - 329
EP - 340
BT - Breast Cancer Metastasis and Drug Resistance
PB - Springer New York
ER -