抄録
The first total synthesis of onchitriol II, a cytotoxic metabolite of mollusc Onchidium sp., is described. It employs mild cyclization method [DMSO - (COCl)2 or Ph3P - CCl4] of triketides bearing optically active functional groups to the corresponding γ-pyrones as a key step. Additional synthesis of some diastereoisomers provided a possibility to revise the structure of closely related onchitriol I.
本文言語 | English |
---|---|
ページ(範囲) | 9581-9584 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 35 |
号 | 51 |
DOI | |
出版ステータス | Published - 1994 12 19 |
外部発表 | はい |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry