Exceptional neurotoxicity is associated with ciguatoxin. The ciguatoxin mimic 1, which contains the F-M framework of the natural product, has been prepared through a convergent synthesis. The two key steps were a Lewis acid mediated intramolecular reaction of a γ-alkoxyallylsilane with an acetal group and an SmI2-mediated intramolecular Reformatsky reaction that permitted construction of the annelated hexahydrooxonin ring system.
|ジャーナル||Angewandte Chemie - International Edition|
|出版ステータス||Published - 1998|
ASJC Scopus subject areas
- 化学 (全般)