Synthetic studies on ciguatoxin: A convergent strategy for construction of the F-M ring framework

Masayuki Inoue, Makoto Sasaki, Kazuo Tachibana

研究成果: Article査読

49 被引用数 (Scopus)

抄録

Exceptional neurotoxicity is associated with ciguatoxin. The ciguatoxin mimic 1, which contains the F-M framework of the natural product, has been prepared through a convergent synthesis. The two key steps were a Lewis acid mediated intramolecular reaction of a γ-alkoxyallylsilane with an acetal group and an SmI2-mediated intramolecular Reformatsky reaction that permitted construction of the annelated hexahydrooxonin ring system.

本文言語English
ページ(範囲)965-969
ページ数5
ジャーナルAngewandte Chemie - International Edition
37
7
DOI
出版ステータスPublished - 1998
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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