Synthetic studies of enacyloxins: A series of antibiotics isolated from frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments

Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Hiroki Hoshikawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota

    研究成果: Article査読

    抄録

    Synthetic studies of enacyloxins (ENXs), a series of yellow-colored, polyene-polyol antibiotics produced by Frateuria sp. W-315, are described. The C1'-C8' polyene fragments were prepared using successive Wittig reactions. The C9'-C15' and C10'-C15' fragments were constructed from (S)-isopropylideneglyceraldehyde using Yamaguchi's nucleophilic substitution reaction of acetylide to epoxide, and/or Marshall's allenylindium mediated reaction as the key steps.

    本文言語English
    ページ(範囲)645-648
    ページ数4
    ジャーナルNatural product communications
    10
    4
    DOI
    出版ステータスPublished - 2015 4月

    ASJC Scopus subject areas

    • 薬理学
    • 植物科学
    • 創薬
    • 補完代替医療

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