Synthetic osteopontin-derived peptide SVVYGLR can induce neovascularization in artificial bone marrow scaffold biomaterials

Yoshinosuke Hamada, Hiroshi Egusa, Yoshitoshi Kaneda, Isao Hirata, Naomasa Kawaguchi, Takafumi Hirao, Takuya Matsumoto, Makiko Yao, Kiyoshi Daito, Mayuka Suzuki, Hirofumi Yatani, Michiharu Daito, Masayuki Okazaki, Nariaki Matsuura

研究成果: Article査読

42 被引用数 (Scopus)

抄録

We have previously reported that an osteopontin-derived SVVYGLR peptide exhibited potent angiogenic activity in vitro and in vivo. In the present study, the focus points were on the in vitro effect of SVVYGLR on bone marrow stromal cell proliferation, as well as its in vivo effect on bone tissue formation when grafts made of CO3Ap-collagen sponge - as a scaffold biomaterial containing the SVVYGLR motif -were implanted. SVVYGLR peptide promoted bone marrow stromal cell proliferation. When a CO3 Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells - as well as prominent angiogenesis - inside the graft could be detected after one week. These results thus suggested that our scaffold biomaterials including the peptide could be useful for bone tissue regeneration.

本文言語English
ページ(範囲)487-492
ページ数6
ジャーナルDental materials journal
26
4
DOI
出版ステータスPublished - 2007 7月
外部発表はい

ASJC Scopus subject areas

  • セラミックおよび複合材料
  • 歯科学(全般)

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