Synthetic approaches towards cortistatins: evolution and progress through its ages

Satrajit Indu, Krishna P. Kaliappan

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

Cortistatins are a family of steroidal alkaloids with a unique pentacyclic skeleton, having immensely potent anti-angiogenetic activities. Given the scarcity in the natural availability of these compounds, their syntheses became major attractions in organic chemistry. Along with total synthesis of the most potent congeners in the family: cortistatins A and J, the synthesis of two other members have been successfully completed, while various other analogues have also been designed with variable degrees of biological activities. This review is an exhaustive coverage of the significant attempts towards constructing this highly challing molecule and also aims to highlight the deep understanding of the structure-activity relationships of these compounds, which have been garnered over time.

本文言語English
ページ(範囲)3965-3995
ページ数31
ジャーナルOrganic and Biomolecular Chemistry
18
21
DOI
出版ステータスPublished - 2020 6 7
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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