Synthesis of triazole-linked analogues of RNA (TLRNA)

Tomoko Fujino, Kenta Endo, Naomi Yamazaki, Hiroyuki Isobe

研究成果: Article査読

9 被引用数 (Scopus)

抄録

A triazole-linked analogue of RNA (TLRNA) has been developed. Monomeric ribonucleoside analogues bearing natural nucleobases were prepared from D-xylose to afford the elongating units in gram quantities. The puckering of the monomeric analogues was similar to that of natural ribonucleosides and preferred the North-type conformation. An efficient elongation reaction via the copper-catalyzed Huisgen cycloaddition on a solid support was used for the synthesis of trinucleotides.

本文言語English
ページ(範囲)403-405
ページ数3
ジャーナルChemistry Letters
41
4
DOI
出版ステータスPublished - 2012 4 24

ASJC Scopus subject areas

  • Chemistry(all)

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