抄録
Awajanomycin, which was isolated from marine-derived fungus, possesses unique structural features and cytotoxic activity against A549 cells. Due to its unique structure, no total synthesis has yet been reported, and neither the relative stereochemistry nor the absolute configuration has been determined. We report the synthesis of the core ring system of awajanomycin, which includes: (i) regioselective addition of the acetate unit onto C4-position of N-Boc-3-methoxycarbonyl-2-pyridinone; (ii) stereoselective installation of a hydroxyl group on C3-position; and (iii) stereo- and regioselective epoxide-opening reaction by Me3Al.
本文言語 | English |
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ページ(範囲) | 2115-2118 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 50 |
号 | 18 |
DOI | |
出版ステータス | Published - 2009 5月 6 |
ASJC Scopus subject areas
- 生化学
- 創薬
- 有機化学