Synthesis of stable analogs in blood and conformational analysis of arenastatin A, a potent cytotoxic spongean depsipeptide

Nobutoshi Murakami, Satoru Tamura, Weiqi Wang, Tatsuya Takagi, Motomasa Kobayashi

研究成果: Article査読

16 被引用数 (Scopus)

抄録

In order to produce stable analogs in blood of arenastatin A, a potent cytotoxic depsipeptide from the marine sponge Dysidea arenaria, we synthesized four analogs in which the 15-20 ester linkage was modified. Among them, the carba analog and 20-deoxo analog showed stability in serum. The conformation of arenastatin A and its three analogs were analyzed by distance-restrained molecular dynamic calculation to elucidate a three-dimensional stereostructure contributing to the extremely potent cytotoxicity of arenastatin A.

本文言語English
ページ(範囲)4323-4336
ページ数14
ジャーナルTetrahedron
57
20
DOI
出版ステータスPublished - 2001 5 14

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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