Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity.

N. Katagiri, M. Nomura, H. Sato, C. Tameda, A. Kurimoto, S. Arai, A. Toyota, C. Kaneko

研究成果: Article査読

4 被引用数 (Scopus)

抄録

The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS.

本文言語English
ページ(範囲)5-6
ページ数2
ジャーナルNucleic acids symposium series
25
出版ステータスPublished - 1991

ASJC Scopus subject areas

  • Medicine(all)

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