抄録
The first synthesis of aspergillide A, a cytotoxin produced by a marine-derived fungus, has been achieved from a synthetic intermediate of aspergillide B by using a proline-mediated epimerization of a 2,6-trans-substituted tetrahydropyran-2-acetaldehyde intermediate into the corresponding cis-isomer via a retro-oxy-Michael/oxy-Michael sequence as the key transformation.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 875-877 |
| ページ数 | 3 |
| ジャーナル | Tetrahedron Letters |
| 巻 | 51 |
| 号 | 5 |
| DOI | |
| 出版ステータス | Published - 2010 2 3 |
ASJC Scopus subject areas
- 生化学
- 創薬
- 有機化学
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
