抄録
The first synthesis of aspergillide A, a cytotoxin produced by a marine-derived fungus, has been achieved from a synthetic intermediate of aspergillide B by using a proline-mediated epimerization of a 2,6-trans-substituted tetrahydropyran-2-acetaldehyde intermediate into the corresponding cis-isomer via a retro-oxy-Michael/oxy-Michael sequence as the key transformation.
本文言語 | English |
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ページ(範囲) | 875-877 |
ページ数 | 3 |
ジャーナル | Tetrahedron Letters |
巻 | 51 |
号 | 5 |
DOI | |
出版ステータス | Published - 2010 2月 3 |
ASJC Scopus subject areas
- 生化学
- 創薬
- 有機化学